Gralewicz Sławomir
Zakład Toksykologii i Kancerogenezy, Instytut Medycyny Pracy im. prof. J. Nofera, Lódź.
Med Pr. 2008;59(2):171-8.
It has long been known that exposure to a stressor may initiate progressive and long-lasting (or even permanent) functional changes in the central nervous system. They are manifested by an altered, decreased or increased responsiveness of the body not only to the generating stressor, but also to other unrelated stressors. Numerous experimental studies have shown that the sensitivity of the body to chemical stressors may be influenced by a prior exposure to nonchemical stressors, e.g., physical or psychological, and vice versa. The purpose of this work is to point out the implications of this observation for epidemiological and experimental studies on health effects of chemical exposure and for establishing the hygiene standards of exposure.
长期以来，人们一直知道暴露于应激源可能会引发中枢神经系统渐进性和长期（甚至永久性）的功能变化。这些变化表现为身体不仅对引发应激源的反应性改变、降低或增加，而且对其他无关应激源的反应性也发生改变。大量实验研究表明，身体对化学应激源的敏感性可能会受到先前暴露于非化学应激源（如物理或心理应激源）的影响，反之亦然。这项工作的目的是指出这一观察结果对化学暴露健康影响的流行病学和实验研究以及确立暴露卫生标准的意义。
