吸烟与年龄相关性黄斑变性风险：一项荟萃分析。

Smoking and the risk of age-related macular degeneration: a meta-analysis.

作者信息

Cong Rihong, Zhou Bo, Sun Qingmin, Gu Haijuan, Tang Naping, Wang Bin

机构信息

Department of Pharmacology, Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.

出版信息

Ann Epidemiol. 2008 Aug;18(8):647-56. doi: 10.1016/j.annepidem.2008.04.002.

DOI:10.1016/j.annepidem.2008.04.002

PMID:18652983

Abstract

PURPOSE

Some studies were undertaken to evaluate the association between cigarette smoking and age-related macular degeneration (AMD). This meta-analysis summarized the risk estimate of smoking and AMD and provided robust evidence for the association.

METHODS

Relevant studies were identified by searching PubMed and MEDLINE (from 1966 to June 2007) and reviewing the reference lists of key articles. The summary relative risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI) were calculated. Study-specific risk estimates were pooled using a random-effects model.

RESULTS

Five prospective cohort and eight case-control studies met our inclusion criteria. Ever smoking was statistically significant associated with increased risk of AMD among cohort studies (RR, 1.61; 95% CI, 1.01-2.57) or case-control studies (RR, 1.76; 95% CI, 1.56-1.99). Current smokers were at higher risk of AMD than past smokers. Both geographic atrophy (GA) and neovascular AMD (NV) are subtypes of AMD. A significant relationship was found between smoking and GA risk. Smoking increased the risk of NV, with marginal nonsignificance (RR, 1.47; 95% CI, 0.92-2.37) in cohort studies and significance in case-control studies (RR, 1.96; 95% CI, 1.69-2.27).

CONCLUSIONS

This meta-analysis indicated smoking, especially current smoking, was significantly associated with increased risks of AMD and its subtypes.

摘要

目的

开展了一些研究以评估吸烟与年龄相关性黄斑变性（AMD）之间的关联。这项荟萃分析总结了吸烟与AMD的风险评估，并为两者之间的关联提供了有力证据。

方法

通过检索PubMed和MEDLINE（1966年至2007年6月）并查阅关键文章的参考文献列表来确定相关研究。计算汇总相对风险比（RR）或比值比（OR）以及95%置信区间（CI）。使用随机效应模型汇总特定研究的风险评估。

结果

五项前瞻性队列研究和八项病例对照研究符合我们的纳入标准。在队列研究（RR，1.61；95%CI，1.01 - 2.57）或病例对照研究（RR，1.76；95%CI，1.56 - 1.99）中，曾经吸烟与AMD风险增加在统计学上具有显著相关性。当前吸烟者患AMD的风险高于既往吸烟者。地图样萎缩（GA）和新生血管性AMD（NV）均为AMD的亚型。发现吸烟与GA风险之间存在显著关系。吸烟增加了NV的风险，在队列研究中接近无显著性（RR，1.47；95%CI，0.92 - 2.37），在病例对照研究中具有显著性（RR，1.96；95%CI，1.69 - 2.27）。