Tariska P, Klein V, Pánczél G, Vitrai J, Knolmayer J, Mészáros A, Urbanics K, Kiss E
Memory Clinic, National Institute of Psychiatry and Neurology, Budapest, 1281 Budapest 27 POB 1, Hungary.
Arch Gerontol Geriatr. 1997 Nov-Dec;25(3):237-43. doi: 10.1016/s0167-4943(97)00015-0.
Vascular risk factors and data of different examinations relating to extracerebral vascular conditions were analysed in demented patients. Data of demented patients subsequently admitted to the Memory Clinic of the National Institute of Psychiatry and Neurology between March 1995 and February 1996 were registered in a specially designed data sheet. Three vascular examinations (ECG, Doppler examination of main extracerebral arteries on the neck, ophthalmoneurological examination) were carried out. The risk factors and vascular alterations were condensed in two factors. Neither the descriptive data nor the two factors showed statistically significant differences in the main groups (probable Alzheimer's disease--n=24, vascular dementia--n=23, mixed forms--n=15). Based on our results: vascular risk factors and pathological changes can occur in probable form of Alzheimer's disease; they can be present in early onset form as well; the most marked changes are in the vascular dementia group; relevant findings lack any correlation with each other in the point of severity of vascular changes. The extremely high cardio-cerebrovascular morbidity in Hungary seems to be reflected in the results. The role of vascular risk factors and (subclinical) pathological findings seem worth exploring further in Alzheimer's disease.
对痴呆患者的血管危险因素以及与脑外血管疾病相关的不同检查数据进行了分析。1995年3月至1996年2月期间，随后入住国立精神病学和神经病学研究所记忆门诊的痴呆患者数据被记录在一张专门设计的数据表中。进行了三项血管检查（心电图、颈部主要脑外动脉的多普勒检查、眼科神经学检查）。危险因素和血管改变被归纳为两个因素。在主要组别（可能的阿尔茨海默病——n = 24、血管性痴呆——n = 23、混合形式——n = 15）中，描述性数据和这两个因素均未显示出统计学上的显著差异。基于我们的结果：血管危险因素和病理变化可出现在可能的阿尔茨海默病形式中；它们也可以早期发病形式存在；最明显的变化出现在血管性痴呆组；在血管变化的严重程度方面，相关发现彼此之间缺乏任何相关性。匈牙利极高的心脑血管发病率似乎在结果中有所体现。血管危险因素和（亚临床）病理发现的作用在阿尔茨海默病中似乎值得进一步探索。
