Fraticelli A, Gambini C, Iannoni E, Paciaroni E
Cardiology Department, Istituto Nazionale di Riposo e Cura per Anziani, Via della Montagnola, 164, Ancona AN I-60131, Italy.
Arch Gerontol Geriatr. 1998 Jul-Aug;27(1):41-7. doi: 10.1016/s0167-4943(98)00016-8.
Paradoxical embolism through a patent foramen ovale (PFO), an increasingly recognized cause of cryptogenic stroke and peripheral embolism, is believed to play little role in the elderly, mainly based on retrospective studies on selected populations. Paradoxical embolism is mostly a presumptive diagnosis, while definite demonstration of a thrombus crossing a PFO is rare. We describe the case of an 84-year-old patient with pulmonary embolism in whom a thrombus in transit through a PFO was found by transesophageal echocardiography (TEE). Treatment with anticoagulants allowed thrombus resolution without evidence of further embolic events. This finding demonstrates that (impending) paradoxical embolism may be present in the 'oldest old'. Its prompt diagnosis may allow effective treatment even with medical therapy alone. We suggest that paradoxical embolism may be not so rare in the elderly. The apparent decline in prevalence with age may be the result of less extensive diagnostic assessment in the elderly, as compared to younger patients.
通过卵圆孔未闭(PFO)发生的矛盾栓塞是不明原因卒中及周围栓塞越来越被认可的病因,基于对特定人群的回顾性研究,人们认为其在老年人中作用不大。矛盾栓塞大多是推定诊断,而明确显示血栓穿过PFO的情况很少见。我们描述了一例84岁肺栓塞患者的病例,经食管超声心动图(TEE)发现有一个血栓正在通过PFO。抗凝治疗使血栓溶解,且无进一步栓塞事件的证据。这一发现表明,“最年长的老年人”中可能存在(即将发生的)矛盾栓塞。即使仅采用药物治疗,其及时诊断也可能实现有效治疗。我们认为矛盾栓塞在老年人中可能并非如此罕见。与年轻患者相比,随着年龄增长其患病率明显下降可能是因为对老年人的诊断评估不够全面。