C-12'位取代长春氟宁衍生物的合成及生物学评价
Synthesis and biological evaluation of C-12' substituted vinflunine derivatives.
作者信息
Lei Xin Sheng, Yu Xiang Da, Yin Long, Liu Zhen Hong, Tang Peng Cho
机构信息
Shanghai Hengrui Pharmaceuticals Co., Ltd., 279 Wenjing Road, Shanghai 200245, China.
出版信息
Bioorg Med Chem Lett. 2008 Aug 15;18(16):4602-5. doi: 10.1016/j.bmcl.2008.07.025. Epub 2008 Jul 12.
PMID:18653334
Abstract
A series of novel C-12' substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines.
摘要
一系列新型的C-12'取代长春氟宁衍生物已被合成。该系列中的几种化合物对A549细胞系具有相当的体外细胞毒性效力。
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