Stoltz M, Oliver D W, Wessels P L, Chalmers A A
College of Pharmacy, University of Pretoria, Republic of South Africa.
J Pharm Sci. 1991 Apr;80(4):357-62. doi: 10.1002/jps.2600800415.
The solid-state 13C NMR spectra of mofebutazone, phenylbutazone, and oxyphenbutazone monohydrate and anhydrate are presented. The crystal structures of these pyrazolidinedione derivatives, obtained by single-crystal X-ray analysis, were previously reported, revealing distinct differences in crystal structure. In this report, the chemical shift values observed for the solid-state 13C spectra are related to the chemical environment of the various carbon atoms and compared with the crystallographic data. Results indicate that solid-state NMR spectroscopy is potentially useful in the study of drugs in the solid state.
本文给出了莫比丁酮、保泰松以及羟基保泰松一水合物和无水物的固态¹³C核磁共振谱。通过单晶X射线分析得到的这些吡唑啉二酮衍生物的晶体结构，此前已有报道，显示出晶体结构存在明显差异。在本报告中，固态¹³C谱观测到的化学位移值与各个碳原子的化学环境相关，并与晶体学数据进行了比较。结果表明，固态核磁共振光谱在固态药物研究中可能具有实用性。
