Derfus B A, Csuka M E, Carrera G F, Hanson G A, Smith R E
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.
J Rheumatol. 1991 May;18(5):738-42.
We describe a patient with viral induced aplastic anemia who developed severe bone pain after treatment with multiple courses of antithymocyte globulin, cyclosporine A, recombinant human granulocyte macrophage colony stimulating factor and deferoxamine. Radiographs and bone biopsy revealed extensive new trabecular bone formation in long bone diaphyses and adjacent periosteal reaction. The effects of hematopoietic growth factors, cyclosporine A and deferoxamine on bone metabolism are reviewed.
我们描述了一名患有病毒诱导的再生障碍性贫血的患者，该患者在接受多疗程抗胸腺细胞球蛋白、环孢素A、重组人粒细胞巨噬细胞集落刺激因子和去铁胺治疗后出现了严重的骨痛。X线片和骨活检显示长骨干骺端有广泛的新小梁骨形成以及相邻的骨膜反应。本文综述了造血生长因子、环孢素A和去铁胺对骨代谢的影响。
