为移植耐受指明道路。
Marking a path to transplant tolerance.
作者信息
Seyfert-Margolis Vicki, Turka Laurence A
机构信息
Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
出版信息
J Clin Invest. 2008 Aug;118(8):2684-6. doi: 10.1172/JCI36552.
Long-term allograft survival requires lifelong immunosuppression, which comes with serious side effects. Inducing immune tolerance to the transplant would enable immunosuppression withdrawal and revolutionize the quality of life of transplant recipients. In this issue of the JCI, Martínez-Llordella et al. identify a profile of biomarkers that predict tolerance in liver transplant recipients (see the related article beginning on page 2845). These findings translate into a new means for prospectively selecting liver transplant patients who would benefit from immunosuppression withdrawal and ultimately may guide development of tolerogenic therapies that allow for allograft acceptance without the use of long-term immunosuppression.
长期的同种异体移植存活需要终身免疫抑制，这会带来严重的副作用。诱导对移植的免疫耐受将使免疫抑制得以撤停，并彻底改变移植受者的生活质量。在本期《临床研究杂志》中，马丁内斯 - 洛尔德拉等人确定了一组可预测肝移植受者耐受情况的生物标志物（见第2845页开始的相关文章）。这些发现转化为一种新方法，可前瞻性地选择能从免疫抑制撤停中获益的肝移植患者，并最终可能指导耐受性疗法的开发，使同种异体移植在不使用长期免疫抑制的情况下被接受。
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