Bernardini Carlotta, D'Arrigo Paola, Elemento Gioia, Mancini Giovanna, Servi Stefano, Sorrenti Alessandro
Dipartimento di Chimica, Università degli Studi di Roma La Sapienza, Roma, Italy.
Chirality. 2009 Jan;21(1):87-91. doi: 10.1002/chir.20610.
The possibility that enantiodiscrimination of bilirubin might be involved in neuronal membrane destabilization, and therefore in bilirubin toxicity, was investigated, by circular dichroism, on model membranes composed of phospholipids. The equilibrium between bilirubin enantiomers is displaced at some extent by the interaction with certain phospholipids. The extent of equilibrium displacement depends on the molecular structure of phospholipids and on the state of charge of bilirubin. The results obtained validate the hypothesis of a possible involvement of chirality in bilirubin toxicity and support a previously suggested model for the molecular mechanism of the interaction of bilirubin with the synaptic membrane.
通过圆二色性，在由磷脂组成的模型膜上研究了胆红素的对映体识别可能参与神经元膜去稳定化，进而参与胆红素毒性的可能性。胆红素对映体之间的平衡在一定程度上会因与某些磷脂的相互作用而发生位移。平衡位移的程度取决于磷脂的分子结构和胆红素的电荷状态。所得结果验证了手性可能参与胆红素毒性的假说，并支持了先前提出的胆红素与突触膜相互作用分子机制的模型。
