Rekas Marek, Wierzbowska Joanna, Lewczuk Katarzyna, Siemiatkowska Anna, Stankiewicz Andrzej
Departament of Ophthalmology, Military Health Service Institute, Warsaw.
Klin Oczna. 2008;110(4-6):145-50.
The purpose of this work was to present effectiveness and safety of phacodeepsclerectomy with SK-gel and T-flux implant in 12 months observation.
Retrospective analysis included group I (SK-gel)--40 eyes and group II (T-flux)--23 eyes. At the control studies best corrected visual acuity (BCVA), intraocular pressure (IOP), anterior and posterior segment of the eye were examined. Control testing was done in the first day and 7-th day, and 1, 3, 6, 12 months after surgery. In the case of elevated IOP (>15 mmHg) goniopuncture was performed. IOP (> 15 mmHg) with fibrosis signs of the filtration bleb was an indication to use antimetabolites. Complete and qualified success rate was defined as IOP < or = 18 mmHg. In statistical analysis one-way ANOVA and Kaplan-Meier survival analysis, were used.
After 12 months mean IOP in the SK-gel group was 12.7 +/- 0.6 mmHg and in T-flux group 14.6 +/- 0.7 mmHg. It was a decrease in the mean IOP by 39.1% (p < .001) and 35.7% (p < .001). In both groups fewer medications were used than before surgery. Complete surgical and qualified success rate was reached in group I (81.7% and 91.9%) and in group II (72.7% and 83.8%). Nd:YAG goniopuncture performed in 10 eyes with implant SK-gel (25.0%) and 6 eyes with implant T-flux (26.1%) (p >.05). Subconjunctival injections with 5-FU were done in 5 eyes in the SK-gel group (12.5%) and in 3 eyes in the T-flux group (13.0%) (p > .05).
Phacodeepsclerectomy (PDS) with SK-gel and T-flux implant are both effective and safe surgical methods in the treatment of POAG in 12 months observation.
本研究旨在呈现12个月观察期内，采用SK凝胶和T-flux植入物的晶状体深层巩膜切除术的有效性和安全性。
回顾性分析包括I组（SK凝胶组）40只眼和II组（T-flux组）23只眼。在对照研究中，检查最佳矫正视力（BCVA）、眼压（IOP）以及眼前段和眼后段。在术后第1天、第7天以及术后1、3、6、12个月进行对照测试。若眼压升高（>15 mmHg），则进行前房角穿刺。眼压>15 mmHg且滤过泡有纤维化迹象时，需使用抗代谢药物。完全成功率和合格成功率定义为眼压≤18 mmHg。统计分析采用单因素方差分析和Kaplan-Meier生存分析。
12个月后，SK凝胶组的平均眼压为12.7±0.6 mmHg，T-flux组为14.6±0.7 mmHg。平均眼压分别降低了39.1%（p<.001）和35.7%（p<.001）。两组术后使用的药物均比手术前减少。I组的完全手术成功率和合格成功率分别为81.7%和91.9%，II组分别为72.7%和83.8%。10只植入SK凝胶的眼（25.0%）和6只植入T-flux的眼（26.1%）进行了Nd:YAG前房角穿刺（p>.05）。SK凝胶组5只眼（12.5%）和T-flux组3只眼（13.0%）进行了5-氟尿嘧啶结膜下注射（p>.05）。
在12个月的观察期内，采用SK凝胶和T-flux植入物的晶状体深层巩膜切除术（PDS）是治疗原发性开角型青光眼（POAG）的有效且安全的手术方法。
