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持续感染水疱性口炎病毒和狂犬病病毒的BHK 21细胞中的RNA合成。

RNA synthesis in BHK 21 cells persistently infected with vesicular stomatitis virus and rabies virus.

作者信息

Villarreal L P, Holland J J

出版信息

J Gen Virol. 1976 Nov;33(2):213-24. doi: 10.1099/0022-1317-33-2-213.

Abstract

Virus-induced RNA synthesis was studied in BHK 21 cells persistently infected with vesicular stomatitis virus (VSV) and rabies virus by labelling RNA synthesized in the presence of antinomycin D. During persistent infection the species of messenger RNA synthesized were similar in size and relative proportions to those seen during acute infection, but there were some minor differences. Full-sized B virion RNA was generally not detected during persistent infection, and new species (probably DI virion RNA) appeared.

摘要

通过在放线菌素D存在的情况下标记合成的RNA,研究了水泡性口炎病毒(VSV)和狂犬病病毒持续感染的BHK 21细胞中病毒诱导的RNA合成。在持续感染期间,合成的信使RNA种类在大小和相对比例上与急性感染期间观察到的相似,但存在一些细微差异。在持续感染期间通常检测不到全长B病毒粒子RNA,并且出现了新的种类(可能是缺陷干扰病毒粒子RNA)。

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