一种肽-聚乙二醇-脂质缀合物的合成方法：奥曲肽-聚乙二醇-二硬脂酰磷脂酰乙醇胺合成的应用。
A synthetic method for peptide-PEG-lipid conjugates: application of octreotide-PEG-DSPE synthesis.
作者信息
Su Jian-Chiou, Tseng Chin-Lu, Chang Ting-Gung, Yu Wen-Jen, Wu Shih-Kwang
机构信息
Department of Medical Research, Kuang Tien General Hospital, 5-2, Datong Street, Shalu, Taichung 43353, Taiwan, ROC.
出版信息
Bioorg Med Chem Lett. 2008 Aug 15;18(16):4593-6. doi: 10.1016/j.bmcl.2008.07.027. Epub 2008 Jul 15.
A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG(2000)-DSPE (OPD(2000)) was used as an example to demonstrate the synthetic approach. The OPD(2000) obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.
建立了一种用于合成肽-聚乙二醇-脂质（peptide-PEG-lipid）偶联物的固相合成方法。以奥曲肽-PEG(2000)-二硬脂酰磷脂酰乙醇胺（OPD(2000)）为例展示合成方法。所获得的OPD(2000)具有确定的结构、活性和纯度，为制备定义明确的药物递送系统（如靶向脂质体）提供了一种靶向分子，以供进一步研究。
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