Peset Isabel, Vernos Isabelle
Cell and Developmental Biology Program, Centre for Genomic Regulation (CRG), University Pompeu Fabra (UPF), Dr Aiguader 88, Barcelona 08003, Spain.
Trends Cell Biol. 2008 Aug;18(8):379-88. doi: 10.1016/j.tcb.2008.06.005. Epub 2008 Jul 23.
A major quest in cell biology is to understand the molecular mechanisms underlying the high plasticity of the microtubule network at different stages of the cell cycle, and during and after differentiation. Initial reports described the centrosomal localization of proteins possessing transforming acidic coiled-coil (TACC) domains. This discovery prompted several groups to examine the role of TACC proteins during cell division, leading to indications that they are important players in this complex process in different organisms. Here, we review the current understanding of the role of TACC proteins in the regulation of microtubule dynamics, and we highlight the complexity of centrosome function.
细胞生物学中的一个主要研究方向是了解微管网络在细胞周期不同阶段以及分化过程中和分化后具有高可塑性的分子机制。最初的报告描述了具有转化酸性卷曲螺旋（TACC）结构域的蛋白质在中心体的定位。这一发现促使多个研究小组研究TACC蛋白在细胞分裂过程中的作用，结果表明它们是不同生物体这一复杂过程中的重要参与者。在此，我们综述了目前对TACC蛋白在微管动力学调节中作用的理解，并强调了中心体功能的复杂性。
