动物模型中舌缩小手术的形态学和组织学结果。
Morphologic and histologic outcomes of tongue reduction surgery in an animal model.
作者信息
Perkins Jonathan A, Shcherbatyy Volodymyr, Liu Zi-Jun
机构信息
Division of Pediatric Otolaryngology, Children's Hospital and Regional Medical Center, Seattle, WA 98105-0371, USA.
出版信息
Otolaryngol Head Neck Surg. 2008 Aug;139(2):291-297. doi: 10.1016/j.otohns.2008.05.018.
OBJECTIVE
To describe the effect of anterior tongue reduction surgery on tongue size, morphology, and histology.
DESIGN
Prospective experiment.
MATERIALS
Twenty-two 12-week-old Yucatan minipigs.
METHODS
Six sibling pairs had tongue reduction (Group B) or sham surgery (Group A), and underwent euthanasia the day of surgery. Five sibling pairs had tongue reduction (Group D) or sham surgery (Group C), and were raised for four weeks. Data collected included changes in tongue morphology, histology, and animal response to surgery.
RESULTS
All animals tolerated surgery and maintained their weight. Tongue size was uniformly reduced in all animals as compared to sham surgery. Tongue reduction was stable long term in Group D. All animals had normal wound healing and neurovascular structure preservation. Fibrosis occurred at the repair site.
CONCLUSION
Midline tongue reduction resulted in uniform tongue reduction in all dimensions and volume, without damaging neurovascular structures. Localized fibrosis is a sequela of healing.
目的
描述舌前部缩小手术对舌头大小、形态和组织学的影响。
设计
前瞻性实验。
材料
22只12周龄的尤卡坦小型猪。
方法
6对同窝仔猪接受舌缩小手术（B组）或假手术（A组），并在手术当天实施安乐死。5对同窝仔猪接受舌缩小手术（D组）或假手术（C组），并饲养4周。收集的数据包括舌头形态、组织学的变化以及动物对手术的反应。
结果
所有动物均耐受手术且体重维持不变。与假手术相比，所有动物的舌头大小均一致减小。D组的舌缩小长期稳定。所有动物伤口愈合正常，神经血管结构得以保留。修复部位出现纤维化。
结论
中线舌缩小术使舌头在所有维度和体积上均一致缩小，且未损害神经血管结构。局部纤维化是愈合的后遗症。
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