Tangri Navdeep, Alam Ahsan, Giannetti Nadia, Deedwardes Michael B, Cantarovich Marcelo
Department of Medicine, McGill University Heath Center, McGill University, Montréal, Québec, Canada.
J Heart Lung Transplant. 2008 Aug;27(8):905-9. doi: 10.1016/j.healun.2008.05.003. Epub 2008 Jul 3.
In this study we evaluated the use of cimetidine on the performance of glomerular filtration rate (GFR) estimating equations and 24-hour creatinine clearance (24-hour CrCl) against radionuclide GFR in 43 heart transplant recipients with stable renal function. Pearson correlation coefficients for the 24-hour CrCl, Cockcroft-Gault, Nankivell and Modification of Diet in Renal Disease study (MDRD) equations without cimetidine were 0.76, 0.70, 0.81 and 0.76, and cimetidine-aided coefficients were 0.82, 0.80, 0.80 and 0.72, respectively. All the tested equations without cimetidine use predicted GFR with moderate accuracy in this population. The addition of cimetidine improved the predictive ability of the 24-hour CrCl and Cockcroft-Gault formulas, but not the Nankivell and MDRD GFR estimating equations, in heart transplant recipients.
在本研究中，我们评估了西咪替丁对43例肾功能稳定的心脏移植受者肾小球滤过率（GFR）估算方程和24小时肌酐清除率（24小时CrCl）相对于放射性核素GFR的性能的影响。未使用西咪替丁时，24小时CrCl、Cockcroft-Gault、Nankivell和肾脏疾病饮食改良研究（MDRD）方程的Pearson相关系数分别为0.76、0.70、0.81和0.76，而使用西咪替丁辅助后的系数分别为0.82、0.80、0.80和0.72。在该人群中，所有未使用西咪替丁的测试方程预测GFR的准确性中等。在心脏移植受者中，添加西咪替丁提高了24小时CrCl和Cockcroft-Gault公式的预测能力，但未提高Nankivell和MDRD GFR估算方程的预测能力。
