Martínez-Sellés Manuel, Datino Tomás, Alhama Marta, Barrueco Nelida, Castillo Isabel, Fernández-Avilés Francisco
Division of Cardiology, Hospital Universitario Gregorio Marañón, Madrid, Spain.
J Heart Lung Transplant. 2008 Aug;27(8):914-6. doi: 10.1016/j.healun.2008.05.008. Epub 2008 Jun 25.
To determine whether carvedilol can be safely up-titrated before hospital discharge, we studied 372 consecutive patients with systolic heart failure who were being treated with carvedilol. Carvedilol was initiated a median of 3 days after admission, with a mean starting dose of 12 mg. Up-titration was performed in 67% of patients, with a mean increase of 16 mg and a mean discharge daily dose of 23 +/- 17 mg. Mean daily dose at the end of follow-up was 35.3 +/- 25.3 mg and it increased with higher discharge dose.
为了确定在出院前卡维地洛是否能安全地增加剂量，我们研究了372例连续使用卡维地洛治疗的收缩性心力衰竭患者。卡维地洛在入院后中位数3天开始使用，平均起始剂量为12毫克。67%的患者进行了剂量上调，平均增加量为16毫克，出院时平均每日剂量为23±17毫克。随访结束时的平均每日剂量为35.3±25.3毫克，且随着出院时较高剂量而增加。
