树脂胶囊：用于平行/组合固相有机合成的可渗透容器。
Resin capsules: permeable containers for parallel/combinatorial solid-phase organic synthesis.
作者信息
Bouillon Isabelle, Soural Miroslav, Krchnák Viktor
机构信息
Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA.
出版信息
J Comb Chem. 2008 Sep-Oct;10(5):714-20. doi: 10.1021/cc800072g. Epub 2008 Jul 26.
Abstract
A resin capsule is a permeable container for resin beads designed for multiple/combinatorial solid-phase organic synthesis. Resin capsules consist of a high density polyethylene ring sealed with peek mesh on both sides. The cylindrical shape of resin capsules enabled space-saving packing into plastic columnlike reaction vessels commonly used for solid-phase organic synthesis. Resin capsules have been evaluated for their use in combinatorial synthesis, and a set of model compounds with excellent purity was prepared.
摘要
树脂胶囊是一种用于树脂珠的可渗透容器，设计用于多重/组合固相有机合成。树脂胶囊由高密度聚乙烯环组成，两侧用聚醚醚酮网密封。树脂胶囊的圆柱形形状使其能够节省空间地装入通常用于固相有机合成的塑料柱状反应容器中。已经对树脂胶囊在组合合成中的应用进行了评估，并制备了一组纯度优异的模型化合物。
相似文献
1
Resin capsules: permeable containers for parallel/combinatorial solid-phase organic synthesis.
J Comb Chem. 2008 Sep-Oct;10(5):714-20. doi: 10.1021/cc800072g. Epub 2008 Jul 26.
2
Large uniform-sized polymer beads for use as solid-phase supports prepared by ascension polymerization.
J Comb Chem. 2006 Jan-Feb;8(1):79-84. doi: 10.1021/cc0500598.
3
Organic selenium resin in solid phase synthesis and its application in constructing medicinally relevant small organic molecules.
Mini Rev Med Chem. 2013 May 1;13(6):854-69. doi: 10.2174/1389557511313060008.
4
Simple tools for resin distribution.
J Comb Chem. 2005 Jan-Feb;7(1):42-5. doi: 10.1021/cc049930v.
5
Microwave-assisted solid-phase synthesis of 2,5-diketopiperazines: solvent and resin dependence.
J Comb Chem. 2006 Nov-Dec;8(6):915-22. doi: 10.1021/cc0600876.
6
Solid-phase synthesis of 3-aminopyrrole-2,5-dicarboxylate analogues.
J Comb Chem. 2006 Jan-Feb;8(1):117-26. doi: 10.1021/cc0500912.
7
Semi-automated high throughput combinatorial solid-phase organic synthesis.
Biotechnol Bioeng. 1998;61(3):135-41. doi: 10.1002/(sici)1097-0290(1998)61:3<135::aid-cc1>3.0.co;2-s.
8
Solid-phase synthesis of 1,2-diheterocyclic-substituted (E)-olefins from a supported selenium resin.
J Comb Chem. 2005 Sep-Oct;7(5):726-33. doi: 10.1021/cc050044+.
9
Solid-phase synthesis of benzofused tricycles based on benzimidazole from resin-bound 3-(2-aminophenylamino)-2-seleno-ester.
J Comb Chem. 2009 Jul-Aug;11(4):515-8. doi: 10.1021/cc900006z.
10
Piperazine amide linker for cyclative cleavage from solid support: traceless synthesis of dihydroquinoxalin-2-ones.
ACS Comb Sci. 2012 Jul 9;14(7):399-402. doi: 10.1021/co300023b. Epub 2012 Jun 18.
引用本文的文献
1
Resins with identical specifications are not identical. Identifying a useful solid-phase resin.
J Comb Chem. 2009 Mar 9;11(2):213-5. doi: 10.1021/cc800143e.
2
Combinatorial libraries of bis-heterocyclic compounds with skeletal diversity.
J Comb Chem. 2008 Nov-Dec;10(6):923-33. doi: 10.1021/cc8001074. Epub 2008 Sep 24.
本文引用的文献
1
Hydroxamate-based iron chelators: combinatorial syntheses of desferrioxamine B analogues and evaluation of binding affinities.
J Comb Chem. 2004 Mar-Apr;6(2):239-54. doi: 10.1021/cc030039a.
2
Solid phase heterocyclic chemistry.
Chem Rev. 2002 Jan;102(1):61-91. doi: 10.1021/cr010123h.
3
Revolutionizing Resin Handling for Combinatorial Synthesis.
Angew Chem Int Ed Engl. 2001 Mar 2;40(5):938-941.
4
Grafted supports in solid-phase synthesis.
Biopolymers. 2000;55(3):207-16. doi: 10.1002/1097-0282(2000)55:3<207::AID-BIP30>3.0.CO;2-F.
5
Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting.
Biotechnol Bioeng. 2000 Winter;71(1):44-50. doi: 10.1002/(sici)1097-0290(200024)71:1<44::aid-bit7>3.0.co;2-j.
6
The domino blocks: a simple solution for parallel solid-phase organic synthesis.
Bioorg Med Chem Lett. 1998 Nov 17;8(22):3261-4. doi: 10.1016/s0960-894x(98)00594-0.
7
Solid-phase peptide synthesis under continuous-flow conditions.
Proc Natl Acad Sci U S A. 1981 May;78(5):2791-5. doi: 10.1073/pnas.78.5.2791.
8
A new general approach for the simultaneous chemical synthesis of large numbers of oligonucleotides: segmental solid supports.
Nucleic Acids Res. 1983 Jul 11;11(13):4365-77. doi: 10.1093/nar/11.13.4365.
9
Gene synthesis technology: recent developments and future prospects.
Biotechnol Appl Biochem. 1988 Dec;10(6):510-21.
10
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.
Proc Natl Acad Sci U S A. 1985 Aug;82(15):5131-5. doi: 10.1073/pnas.82.15.5131.
Zotero 插件