具有骨架多样性的双杂环化合物组合文库。
Combinatorial libraries of bis-heterocyclic compounds with skeletal diversity.
作者信息
Soural Miroslav, Bouillon Isabelle, Krchnák Viktor
机构信息
Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA.
出版信息
J Comb Chem. 2008 Nov-Dec;10(6):923-33. doi: 10.1021/cc8001074. Epub 2008 Sep 24.
Abstract
Combinatorial solid-phase synthesis of bis-heterocyclic compounds, characterized by the presence of two heterocyclic cores connected by a spacer of variable length/structure, provided structurally heterogeneous libraries with skeletal diversity. Both heterocyclic rings were assembled on resin in a combinatorial fashion.
摘要
双杂环化合物的组合固相合成，其特征在于存在由可变长度/结构的间隔基连接的两个杂环核心，提供了具有骨架多样性的结构异质文库。两个杂环均以组合方式在树脂上组装。
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