McDevitt Christopher A, Shintre Chitra A, Grossmann J Günter, Pollock Naomi L, Prince Stephen M, Callaghan Richard, Ford Robert C
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
FEBS Lett. 2008 Aug 20;582(19):2950-6. doi: 10.1016/j.febslet.2008.07.022. Epub 2008 Jul 25.
P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.
P-糖蛋白（ABCB1）是一种ATP结合盒蛋白，与癌症中多药耐药性的获得以及人类化疗失败有关。利用小角X射线散射数据和冷冻电子晶体学数据相结合的方法描述了该蛋白的结构见解。我们将这些结构与细菌同源物进行了比较，并讨论了基于细菌Sav1866结构的P-糖蛋白同源模型的发展。
