Bogatcheva Natalia V, Verin Alexander D
Medical College of Georgia, Vascular Biology Center, Augusta, GA 30912, USA.
Microvasc Res. 2008 Nov;76(3):202-7. doi: 10.1016/j.mvr.2008.06.003. Epub 2008 Jun 28.
The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cell monolayer in quiescent endothelium, and to enable the disintegration of the formed barrier in response to various agonists. Vascular permeability is defined by the combination of transcellular and paracellular pathways, with the latter being a major contributor to the inflammation-induced barrier dysfunction. This review will analyze the cytoskeletal elements, which reorganization affects endothelial permeability, and emphasize signaling mechanisms with barrier-protective or barrier-disruptive potential.
细胞骨架对于机体中几乎所有细胞类型的功能都至关重要，因为细胞分裂、细胞运动、胞吞或胞吐作用以及细胞形状的维持都需要它。血管内表面的内皮细胞利用细胞骨架成分来确保静止内皮中细胞单层的完整性，并在响应各种激动剂时使形成的屏障解体。血管通透性由跨细胞途径和细胞旁途径共同决定，后者是炎症诱导的屏障功能障碍的主要促成因素。本综述将分析其重组会影响内皮通透性的细胞骨架成分，并强调具有屏障保护或屏障破坏潜力的信号传导机制。
