Roozendaal Benno, Castello Nicholas A, Vedana Gustavo, Barsegyan Areg, McGaugh James L
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA.
Neurobiol Learn Mem. 2008 Oct;90(3):576-9. doi: 10.1016/j.nlm.2008.06.010. Epub 2008 Aug 12.
Noradrenergic activation of the basolateral complex of the amygdala (BLA) modulates the consolidation of memory for many kinds of highly emotionally arousing training tasks. The present experiments investigated whether posttraining noradrenergic activation of the BLA is sufficient to enable memory consolidation of a low-arousing training experience. Sprague-Dawley rats received intra-BLA infusions of norepinephrine, the beta-adrenoceptor antagonist propranolol or saline immediately after either 3 or 10 min of object recognition training. Saline-infused controls exhibited poor 24-h retention when given 3 min of object recognition training and good retention when given 10 min of training. Norepinephrine administered after 3 min of object recognition training produced dose-dependent enhancement of 24-h object recognition memory whereas propranolol administered after 10 min of training produced dose-dependent impairment of memory. These findings provide evidence that posttraining noradrenergic activation of the BLA enhances memory of a low-arousing training experience that would otherwise not induce long-term memory. Thus, regardless of the degree of emotional arousal induced by an experience, noradrenergic activation of the BLA after the experience ensures that it will be better remembered.
杏仁核基底外侧复合体（BLA）的去甲肾上腺素能激活作用可调节多种高度情绪化唤醒训练任务的记忆巩固。本实验研究了训练后BLA的去甲肾上腺素能激活是否足以使低唤醒训练经历的记忆得到巩固。斯普拉格-道利大鼠在进行3分钟或10分钟的物体识别训练后，立即接受BLA内注射去甲肾上腺素、β-肾上腺素能受体拮抗剂普萘洛尔或生理盐水。注射生理盐水的对照组在接受3分钟物体识别训练后24小时的记忆保持较差，而在接受10分钟训练后记忆保持良好。在3分钟物体识别训练后注射去甲肾上腺素可产生剂量依赖性增强24小时物体识别记忆的效果，而在10分钟训练后注射普萘洛尔则产生剂量依赖性记忆损害。这些发现提供了证据，表明训练后BLA的去甲肾上腺素能激活增强了低唤醒训练经历的记忆，否则该经历不会诱导长期记忆。因此，无论经历所引发的情绪唤醒程度如何，经历后BLA的去甲肾上腺素能激活都能确保该经历被更好地记住。
