Rechavi G, Katzir N, Ramot B
Department of Haematology, Chaim Sheba Medical Centre, Tel-Hashomer, Israel.
Med Hypotheses. 1991 Apr;34(4):338-41. doi: 10.1016/0306-9877(91)90051-y.
The epidemiologic findings of Kaposi's sarcoma (KS) among patients with the acquired immunodeficiency syndrome (AIDS) suggest that human immunodeficiency virus (HIV) infection is insufficient for the development of KS. It was speculated that another sexually transmitted infection is responsible for the markedly increased incidence of KS among patients who acquired HIV infection through sexual intercourse. However, no such contributing infectious agent was consistently identified. The canine transmissible venereal tumour (TVT) is a malignant tumour that can be transplanted by viable cells across major histocompatibility complex (MHC) barriers. Recent findings suggest that all canine TVTs originated from the same tumour and were transferred from one animal to the other during sexual intercourse. It is suggested that, in analogy with the canine TVT model, the characteristics of KS epidemic among AIDS patients may be explained by transmission and engraftment of viable malignant cells during intercourse.
卡波西肉瘤（KS）在获得性免疫缺陷综合征（AIDS）患者中的流行病学研究结果表明，人类免疫缺陷病毒（HIV）感染不足以引发KS。据推测，另一种性传播感染是通过性交感染HIV的患者中KS发病率显著增加的原因。然而，一直未能确定这样一种起作用的传染因子。犬传染性性病肿瘤（TVT）是一种恶性肿瘤，其活细胞可跨越主要组织相容性复合体（MHC）屏障进行移植。最近的研究结果表明，所有犬TVT均起源于同一肿瘤，并在性交过程中从一只动物传播至另一只动物。有人提出，类比犬TVT模型，AIDS患者中KS流行的特征可能是由于性交过程中活的恶性细胞的传播和植入所致。
