Yamada N, Bilkey D K
Department of Psychology, University of Otago, Dunedin, New Zealand.
Neuropharmacology. 1991 May;30(5):501-5. doi: 10.1016/0028-3908(91)90013-2.
The effects of nifedipine, an antagonist of voltage-operated calcium channels, on the development of amygdala kindling and on the production of fully kindled seizures, stimulated from the amygdala, were investigated. Rats were treated daily with two doses (5 and 50 mg/kg, i.p.) of nifedipine during the development of kindling. Both doses of nifedipine retarded the development of kindled seizures and 50 mg/kg of nifedipine prolonged the latency to the occurrence of bilateral forelimb clonus. In contrast to these antiepileptogenic effects, however, both doses also increased the duration of afterdischarge. This resulted in a striking increase in the cumulative duration of afterdischarge, required to reach stage 4 and 5 seizures. Contrary to the results of a previous study, 50 mg/kg of nifedipine did not produce any significant effect on fully kindled seizures, regardless of the interval (5 min-24 hr) between injection and stimulation of kindling. These results suggested that although nifedipine inhibited the propagation processes of seizures during development of kindling, it appeared to increase the duration of epileptic activity at the kindling focus.
研究了电压门控钙通道拮抗剂硝苯地平对杏仁核点燃的发展以及对由杏仁核刺激引发的完全点燃性癫痫发作产生的影响。在点燃发展过程中，每天给大鼠腹腔注射两种剂量（5和50毫克/千克）的硝苯地平。两种剂量的硝苯地平均延缓了点燃性癫痫发作的发展，且50毫克/千克的硝苯地平延长了双侧前肢阵挛发作的潜伏期。然而，与这些抗癫痫发生作用相反，两种剂量均增加了放电后持续时间。这导致达到4期和5期癫痫发作所需的放电后累积持续时间显著增加。与先前一项研究的结果相反，无论注射与点燃刺激之间的间隔（5分钟至24小时）如何，50毫克/千克的硝苯地平对完全点燃性癫痫发作均未产生任何显著影响。这些结果表明，尽管硝苯地平在点燃发展过程中抑制了癫痫发作的传播过程，但它似乎增加了点燃灶处癫痫活动的持续时间。
