经典的肢体模式形成模型与丹尼斯·萨默贝尔的研究工作。
Classic limb patterning models and the work of Dennis Summerbell.
作者信息
Galloway Jenna L, Tabin Clifford J
机构信息
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
出版信息
Development. 2008 Aug;135(16):2683-7. doi: 10.1242/dev.021188.
Abstract
Dennis Summerbell was a leading contributor to our understanding of limb patterning prior to the advent of molecular biology. He published several groundbreaking papers, including one that developed a key model for patterning the limb from the shoulder to the fingertips and another that presented the co-discovery of the effect of retinoids on limb morphogenesis. He brought detailed quantitative analyses to bear on these studies, as highlighted in two of his insightful papers published in the Journal of Embryology and Experimental Morphology, in which he provided elegant models that, today, remain relevant to limb patterning, as well as to many disciplines of developmental biology.
摘要
在分子生物学出现之前，丹尼斯·萨默贝尔对我们理解肢体模式做出了重要贡献。他发表了几篇具有开创性的论文，其中一篇建立了一个从肩部到指尖的肢体模式关键模型，另一篇共同发现了视黄酸对肢体形态发生的影响。他将详细的定量分析应用于这些研究，这在他发表于《胚胎学与实验形态学杂志》的两篇有深刻见解的论文中得到了体现，在这两篇论文中，他提供了精妙的模型，这些模型至今仍与肢体模式以及发育生物学的许多学科相关。
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