The diastereoselective synthesis of methyl 5-deoxy-5-(dialkylphosphono)-5-(dialkylphosphorylamido)-2,3-O-isopropylidene-beta-D-ribofuranosides.

作者信息

Cui Zhanwei, Zhang Jianfeng, Wang Fei, Wang Yadan, Miao Zhiwei, Chen Ruyu

机构信息

State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China.

出版信息

Carbohydr Res. 2008 Oct 13;343(15):2530-4. doi: 10.1016/j.carres.2008.06.009. Epub 2008 Jun 14.

A convenient method has been developed for the diastereoselective synthesis of methyl 5-deoxy-5-(dialkylphosphono)-5-(dialkylphosphorylamido)-2,3-O-isopropylidene-beta-d-ribofuranosides under mild conditions, namely the reaction of a dialkyl phosphoramidate with a dialkyl phosphite and methyl 2,3-O-isopropylidene-beta-D-ribo-pentodialdo-1,4-furanoside in acetyl chloride in a one-pot procedure.