Zou Mei, Wang Hai-Feng, Hu Jian-Min
Shenyang Agricultural University, Shenyang 110161, China.
Sheng Li Ke Xue Jin Zhan. 2008 Apr;39(2):139-44.
Proteomics, a hot new research area studied by biologists in the post-genome era, leads an integrated study of the expression and function of proteins on a large scale. Epididymis is responsible for the sperm maturation and storage, and its gene expression is highly region-specific, so it maybe an ideal model for proteomics, especially for differential proteomics study. This paper gives a brief introduction of the application of proteomics in the epididymis and the differential proteins expressed in different epididymal regions. These epididymis-specific/selective proteins identified by proteomics technology may prove to be targets for contraception or may provide insight to the unique responsibilities of the epididymis in supporting male fertility.
蛋白质组学是后基因组时代生物学家研究的一个热门新领域，它大规模地对蛋白质的表达和功能进行综合研究。附睾负责精子的成熟和储存，其基因表达具有高度的区域特异性，因此它可能是蛋白质组学，特别是差异蛋白质组学研究的理想模型。本文简要介绍了蛋白质组学在附睾中的应用以及在附睾不同区域表达的差异蛋白质。通过蛋白质组学技术鉴定出的这些附睾特异性/选择性蛋白质可能被证明是避孕的靶点，或者可能为附睾在支持男性生育方面的独特作用提供见解。
