Mao Yong-Jun, Li Hai-Hong, Li Jian-Feng, Shen Jing-Shan
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Yao Xue Xue Bao. 2008 Apr;43(4):323-34.
Intracellular signal transduction plays an important role in the process of cellular metabolism, segmentation, differentiation, biological behaviour and cell death. Overactive signal transduction relates to tumor development and progression. Signaling pathways operated by protein tyrosine kinases (PTKs) will be illuminated here briefly. The Ras/Raf/MAPK and PI-3K/Akt pathways through receptor protein tyrosine kinases (RTKs), the Src, Bcr-Abl and JAK/STAT pathways by non-receptor protein tyrosine kinases (nrPTKs) are shown separately. Antitumor agents targeting the key proteins involved in the above five signalling routes are also summarized in this review.
细胞内信号转导在细胞代谢、分裂、分化、生物学行为及细胞死亡过程中发挥着重要作用。信号转导过度活跃与肿瘤的发生和发展相关。本文将简要阐述由蛋白酪氨酸激酶（PTK）介导的信号通路。通过受体蛋白酪氨酸激酶（RTK）介导的Ras/Raf/MAPK和PI-3K/Akt信号通路，以及由非受体蛋白酪氨酸激酶（nrPTK）介导的Src、Bcr-Abl和JAK/STAT信号通路将分别展示。本文还总结了针对上述五条信号通路中关键蛋白的抗肿瘤药物。
