Tian Jian-hui, Shi Zhi-ming, Zhou Zhi-yi, Huang Yun-sheng, Wang Lin
Department of Oncology, Shanghai Municipal Clinical Medicine Center for Chinese Traditional Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Zhong Xi Yi Jie He Xue Bao. 2008 Aug;6(8):827-9. doi: 10.3736/jcim20080811.
To observe the effects of Feiji Formula, a compound traditional Chinese herbal medicine, on lung cancer metastasis in mice.
The lung cancer metastasis model of mice was established in this experiment study. Twenty-four mice were randomly divided into three groups: untreated group, cisplatin group and Feiji Formula group. Mice in the Feiji Formula group were treated with Feiji Formula decoction; in cisplatin group, with cisplatin by intraperitoneal injection; and in the untreated group, with normal saline (NS). After twenty-day treatment, the body and tumor weights as well as the number of metastatic tumors in both lungs of each mouse were measured.
The body weight of mice in cisplatin group was significantly less than that of Feiji Formula group and untreated group (P<0.01); the tumor weight of mice in cisplatin group and Feiji Formula group was markedly lower than that of untreated group (P<0.01); and the number of metastatic tumors in cisplatin group and Feiji Formula group was markedly lower than that of the untreated group (P<0.01), no significant difference between the Feiji Formula group and cisplatin group in terms of the weights and the numbers of metastatic tumors in bilateral lungs.
Feiji Formula can suppress tumor growth and decrease the number of lung metastatic tumors in the mice, and maintain the body weight of the mice.
观察复方中药肺积方对小鼠肺癌转移的影响。
本实验研究建立小鼠肺癌转移模型。将24只小鼠随机分为三组：未治疗组、顺铂组和肺积方组。肺积方组小鼠用肺积方水煎剂治疗；顺铂组小鼠腹腔注射顺铂；未治疗组小鼠给予生理盐水。治疗20天后，测量每只小鼠的体重、肿瘤重量以及双肺转移瘤的数量。
顺铂组小鼠体重显著低于肺积方组和未治疗组（P<0.01）；顺铂组和肺积方组小鼠的肿瘤重量明显低于未治疗组（P<0.01）；顺铂组和肺积方组的肺转移瘤数量明显低于未治疗组（P<0.01），肺积方组与顺铂组在双侧肺转移瘤的重量和数量方面无显著差异。
肺积方能抑制小鼠肿瘤生长，减少肺转移瘤数量，并维持小鼠体重。
