台湾杉树皮中的18-去甲罗汉松烷类和罗汉松烷类化合物。

18-nor-Podocarpanes and podocarpanes from the Bark of Taiwania cryptomerioides.

作者信息

Chien Shih-Chang, Chen Cheng-Chi, Chiu Hsi-Lin, Chang Chi-I, Tseng Mei-Hwei, Kuo Yueh-Hsiung

机构信息

Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan, ROC.

出版信息

Phytochemistry. 2008 Sep;69(12):2336-40. doi: 10.1016/j.phytochem.2008.06.005. Epub 2008 Jul 27.

DOI:10.1016/j.phytochem.2008.06.005

PMID:18664396

Abstract

Seven nor- and podocarpane-type diterpenes were isolated from the bark of Taiwania cryptomerioides Hayata, including three 18-nor-podocarpanes: 18-nor-1beta,4alpha,14-trihydroxy-13-methoxy-8,11,13-podocarpatriene (1), 18-nor-1beta,4alpha,13,14-tetrahydroxy-8,11,13-podocarpatrien-7-one (2), 18-nor-1beta,4alpha,14-trihydroxy-13-methoxy-8,11,13-podocarpatrien-7-one (3), 1beta,14,19-trihydroxy-13-methoxy-8,11,13-podocarpatrien-7-one (4), 1beta,13,14,18-tetrahydroxy-8,11,13-podocarpatrien-7-one (5), 18-acetoxy-1beta,13,14-trihydroxy-8,11,13-podocarpatrien-7-one (6), and 1beta,14,18-trihydroxy-13-methoxy-8,11,13-podocarpatrien-7-one (7). Their structures were determined by application of 1D and 2D NMR spectroscopy and other techniques. Podocarpane-type diterpenes do not occur extensively in nature, and the presumed oxidative enzyme in this plant will be of interest to identify.

摘要

从台湾杉的树皮中分离出七种降蒈烷型和罗汉松烷型二萜，包括三种18-降罗汉松烷：18-降-1β,4α,14-三羟基-13-甲氧基-8,11,13-罗汉松三烯（1）、18-降-1β,4α,13,14-四羟基-8,11,13-罗汉松三烯-7-酮（2）、18-降-1β,4α,14-三羟基-13-甲氧基-8,11,13-罗汉松三烯-7-酮（3）、1β,14,19-三羟基-13-甲氧基-8,11,13-罗汉松三烯-7-酮（4）、1β,13,14,18-四羟基-8,11,13-罗汉松三烯-7-酮（5）、18-乙酰氧基-1β,13,14-三羟基-8,11,13-罗汉松三烯-7-酮（6）和1β,14,18-三羟基-13-甲氧基-8,11,13-罗汉松三烯-7-酮（7）。它们的结构通过一维和二维核磁共振光谱以及其他技术确定。罗汉松烷型二萜在自然界中分布不广泛，鉴定这种植物中推测的氧化酶将是一件有趣的事情。