Wu J C, Gillin J C, Buchsbaum M S, Hershey T, Hazlett E, Sicotte N, Bunney W E
University of California, Irvine.
Sleep. 1991 Apr;14(2):155-62.
This study is the first report on the effects of total sleep deprivation (about 32 h) on regional cerebral glucose metabolism during wakefulness in man, using positron emission tomography (PET) with F-18 deoxyglucose (FDG). Sleep deprivation leads to a significant reorganization of regional cerebral metabolic activity, with relative decreases in the temporal lobes and increases in visual cortex. Absolute glucose metabolic measurements indicate a decrease in thalamus, basal ganglia, white matter, and cerebellum. No overall decrease in whole brain metabolism was noted after sleep deprivation. As expected, sleep deprivation significantly reduced visual vigilance as assessed by the continuous performance test and this decrease was correlated significantly with reduced metabolic rate in thalamic, basal ganglia, and limbic regions.
本研究首次报告了使用F-18脱氧葡萄糖（FDG）正电子发射断层扫描（PET）技术，在人类清醒状态下完全睡眠剥夺（约32小时）对局部脑葡萄糖代谢的影响。睡眠剥夺导致局部脑代谢活动显著重新组织，颞叶相对代谢降低，视觉皮层代谢增加。绝对葡萄糖代谢测量显示丘脑、基底神经节、白质和小脑代谢降低。睡眠剥夺后未发现全脑代谢总体下降。正如预期的那样，通过连续操作测试评估，睡眠剥夺显著降低了视觉警觉性，这种降低与丘脑、基底神经节和边缘区域代谢率降低显著相关。
