Pagovich Odelya E, Silverberg Jonathan I, Freilich Elie, Silverberg Nanette B
Sackler University, Tel Aviv, Israel.
Cutis. 2008 Jun;81(6):463-6.
The link between vitiligo and thyroid disease has been well-established. However, the types of patients at risk for thyroid disease and the strength of this connection in childhood are debatable. We retrospectively reviewed 67 charts of pediatric dermatology patients with vitiligo vulgaris (53 with nonsegmental vitiligo) who were tested for thyroid disease. In our cohort of 28 patients with available thyroid test results, we identified 7 patients (25%) with active thyroid disease. None of the 7 patients with thyroid disease had segmental vitiligo. If we had included the broader number of patients (N=67), the rate may have been as low as 10.4% overall (7/67), which is still a substantial rate of thyroid disease. These results are comparable to the European literature and highlight the need for thyroid screening in children with vitiligo vulgaris of a generalized nonsegmental type.
白癜风与甲状腺疾病之间的联系已得到充分证实。然而,甲状腺疾病的高危患者类型以及这种联系在儿童期的强度仍存在争议。我们回顾性分析了67例患有寻常型白癜风(53例为非节段性白癜风)的儿科皮肤科患者的病历,这些患者均接受了甲状腺疾病检测。在我们这组有可用甲状腺检测结果的28例患者中,我们确定了7例(25%)患有活动性甲状腺疾病。7例患有甲状腺疾病的患者均无节段性白癜风。如果我们纳入更多患者(N = 67),总体患病率可能低至10.4%(7/67),但这仍然是一个相当高的甲状腺疾病患病率。这些结果与欧洲文献相当,并突出了对泛发性非节段型寻常型白癜风儿童进行甲状腺筛查的必要性。