Pintado V, Valencia M E, López-Dupla J M, Lavilla P, Feliú J, Gil A
Servicio de Medicina Interna, Hospital La Paz, Madrid.
Sangre (Barc). 1991 Apr;36(2):141-3.
Mucormycosis is a rare infection that occurs in immunocompromised patients. The rhinocerebral form presents in diabetics as a severe necrotizing sinusitis and is not frequent in patients with haematologic malignancies. Diagnosis requires direct examination and culture of biopsy specimens. Two patients with rhinocerebral mucormycosis and haematologic neoplasms (Non-Hodgkin's lymphoma and acute myeloblastic leukaemia) are described. Both patients had severe drug-induced neutropenia when the infection appeared. One patient died in spite of aggressive treatment with surgery and amphotericin.
毛霉菌病是一种发生于免疫功能低下患者的罕见感染。鼻脑型在糖尿病患者中表现为严重的坏死性鼻窦炎，在血液系统恶性肿瘤患者中并不常见。诊断需要对活检标本进行直接检查和培养。本文描述了两名患有鼻脑型毛霉菌病和血液系统肿瘤（非霍奇金淋巴瘤和急性髓细胞白血病）的患者。两名患者在感染出现时均有严重的药物性中性粒细胞减少。尽管进行了手术和两性霉素的积极治疗，一名患者仍死亡。
