钙在神经元发育过程中帮助其识别突触靶点。
Calcium helps neurons identify synaptic targets during development.
作者信息
Berglund Ken, Augustine George J
机构信息
Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
出版信息
Neuron. 2008 Jul 31;59(2):186-7. doi: 10.1016/j.neuron.2008.07.016.
Abstract
Correct wiring of brain circuitry during development involves the selective formation and retention of synaptic connections between neurons. In this issue of Neuron, Lohmann and Bonhoeffer show that dendritic filopodia can distinguish among prospective presynaptic axonal targets during development. Contact with the appropriate target triggers local calcium signals that stabilize the filopodia and tell them to form mature synapses.
摘要
大脑回路在发育过程中的正确布线涉及神经元之间突触连接的选择性形成和保留。在本期《神经元》杂志中，洛曼和博恩霍费尔表明，树突丝状伪足在发育过程中能够区分潜在的突触前轴突靶点。与合适的靶点接触会触发局部钙信号，从而稳定丝状伪足并促使它们形成成熟的突触。
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本文引用的文献
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