The binding of antibiotics to ERp57/GRP58.
作者信息
Gaucci Elisa, Chichiarelli Silvia, Grillo Caterina, Vecchio Emiliana Del, Eufemi Margherita, Turano Carlo
机构信息
Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Sapienza-Università di Roma, Italy.
出版信息
J Antibiot (Tokyo). 2008 Jun;61(6):400-2. doi: 10.1038/ja.2008.56.
PMID:18667789
Abstract
The effects of five antibiotics, previously described as ligands of protein disulfide isomerase PDI, have now been studied on the homologous protein ERp57. They bind to this protein with much higher affinity than to PDI, and some of them inhibit the reductase and the DNA-binding activities of ERp57. In view of the high affinity of vancomycin, erythromycin and streptomycin, some effects of their interaction with this protein might be expected in vivo.
摘要
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