Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Sapienza, Università di Roma, Roma, Italy.
Cell Mol Biol Lett. 2011 Dec;16(4):539-63. doi: 10.2478/s11658-011-0022-z. Epub 2011 Aug 11.
The protein ERp57/GRP58 is a stress-responsive protein and a component of the protein disulfide isomerase family. Its functions in the endoplasmic reticulum are well known, concerning mainly the proper folding and quality control of glycoproteins, and participation in the assembly of the major histocompatibility complex class 1. However, ERp57 is present in many other subcellular locations, where it is involved in a variety of functions, primarily suggested by its participation in complexes with other proteins and even with DNA. While in some instances these roles need to be confirmed by further studies, a great number of observations support the participation of ERp57 in signal transduction from the cell surface, in regulatory processes taking place in the nucleus, and in multimeric protein complexes involved in DNA repair.
蛋白 ERp57/GRP58 是一种应激反应蛋白，也是蛋白质二硫键异构酶家族的一个组成部分。其在 ER 中的功能是众所周知的，主要涉及糖蛋白的正确折叠和质量控制，以及参与主要组织相容性复合体 I 类的组装。然而，ERp57 存在于许多其他亚细胞位置，在那里它参与了各种功能，主要是通过与其他蛋白质甚至 DNA 的复合物参与。虽然在某些情况下，这些作用需要通过进一步的研究来证实，但大量的观察结果支持 ERp57 参与细胞表面信号转导、核内调节过程以及参与 DNA 修复的多聚体蛋白复合物。
