Djurhuus M S, Klitgaard N A, Beck-Nielsen H
Odense Sygehus, klinisk kemisk afdeling og medicinsk-endokrinologisk afdeling M.
Ugeskr Laeger. 1991 Jul 22;153(30):2108-10.
Diabetics have a higher prevalence of recurrent angina, myocardial infarction and hypertension compared with healthy individuals. This is partly due to the metabolic control, and partly to the development of nephropathy, but inherited factors also seem to contribute to their development. Another factor, to some extent inherited, could be magnesium-deficiency. Up to 30% of all diabetics suffer from magnesiumdepletion, which in other disease entities has been related to angina pectoris, myocardial infarction, and changes in blood lipids. Furthermore, magnesium-deficiency might be related to the development of hypertension. In diabetes, magnesium-depletion has been linked with the development of retinopathy, and an increase in abortions and malformations in diabetic pregnancies. No intervention trials with magnesium, to elucidate the question of magnesium depletion and diabetic late complications have hitherto been made. No methods for assessing magnesium-status in diabetes are available as yet, to select patients for this type of trial.
与健康个体相比，糖尿病患者复发性心绞痛、心肌梗死和高血压的患病率更高。这部分归因于代谢控制，部分归因于肾病的发展，但遗传因素似乎也在其中起作用。另一个在一定程度上由遗传决定的因素可能是镁缺乏。高达30%的糖尿病患者存在镁缺乏，在其他疾病中，镁缺乏与心绞痛、心肌梗死和血脂变化有关。此外，镁缺乏可能与高血压的发生有关。在糖尿病中，镁缺乏与视网膜病变的发展以及糖尿病妊娠中流产和畸形的增加有关。迄今为止，尚未进行过用镁进行的干预试验来阐明镁缺乏与糖尿病晚期并发症的问题。目前还没有评估糖尿病患者镁状态的方法来选择这类试验的患者。
