新型不透射线甲基丙烯酸甲酯-甲基丙烯酸缩水甘油酯基聚合物的生物医学应用研究。

Studies on novel radiopaque methyl methacrylate: glycidyl methacrylate based polymer for biomedical applications.

机构信息

Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695012, Kerala, India.

出版信息

J Mater Sci Mater Med. 2009 Dec;20 Suppl 1:S243-50. doi: 10.1007/s10856-008-3557-4. Epub 2008 Jul 31.

DOI:10.1007/s10856-008-3557-4

PMID:18668209

Abstract

A new class of radiopaque copolymer using methyl methacrylate (MMA) and glycidyl methacrylate (GMA) monomers was synthesized and characterized. The copolymer was made radiopaque by the epoxide ring opening of GMA using the catalyst o-phenylenediamine and the subsequent covalent attachment of elemental iodine. The copolymer was characterized by Fourier transform infrared (FTIR) spectra, energy dispersive X-ray analysis using environmental scanning electron microscope (EDAX), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). X-ray visibility of the copolymer was checked by X-radiography. Blood compatibility and cytotoxicity of the newly synthesized copolymer were also evaluated. The iodinated copolymer was thermally stable, blood compatible, non-cytotoxic, and highly radiopaque. The presence of bulky iodine group created a new copolymer with modified properties for potential use in biomedical applications.

摘要

采用甲基丙烯酸甲酯（MMA）和甲基丙烯酸缩水甘油酯（GMA）单体合成了一类新型的放射线可检测的共聚物，并对其进行了表征。通过 o-苯二胺作为催化剂打开 GMA 的环氧化物环，随后用元素碘进行共价键合，使共聚物具有放射线可检测性。通过傅里叶变换红外（FTIR）光谱、环境扫描电子显微镜（EDAX）的能量色散 X 射线分析、热重分析（TGA）和差示扫描量热法（DSC）对共聚物进行了表征。通过 X 射线照相检查了共聚物的 X 射线可见度。还评估了新合成的共聚物的血液相容性和细胞毒性。碘化共聚物热稳定性好、血液相容性好、无细胞毒性、放射线可检测性高。大体积碘基团的存在赋予了共聚物新的特性，为其在生物医学应用中的潜在用途提供了可能。