Kruft M A, Benzina A, Bär F, van der Veen F H, Bastiaansen C W, Blezer R, Lindhout T, Koole L H
Biomaterials and Polymer Research Institute Maastricht-Eindhoven (Bioprime), University of Limburg, The Netherlands.
J Biomed Mater Res. 1994 Nov;28(11):1259-66. doi: 10.1002/jbm.820281103.
Two new polymeric materials (polymers A and B) containing covalently bound iodine were prepared. These polymers were evaluated with respect to their possible use as radiopaque implant biomaterials--that is, materials that are visible in a noninvasive manner using routine X-ray absorption imaging techniques. Polymer A is a copolymer of methyl methacrylate (MMA) and 1 (80 and 20 mol%, respectively). Polymer B was prepared from MMA, 1, and 2-hydroxyethyl methacrylate (HEMA) (mol ratio 65:20:15, respectively). Compound 1 was synthesized from 4-iodophenol and methacryloyl chloride. The resulting polymers were characterized with GPC, DSC, NMR, and by measuring both the advancing and receding contact angles. Thrombogenicity of the polymers was determined by an in vitro thrombin generation test procedure. The maximum concentration of free thrombin was 76 +/- 1 nM for polymer A, and 64 +/- 3 nM for polymer B. The lag times (i.e., time onset of thrombin generation) were 392 seconds for polymer A and 553 seconds for polymer B. For PVC-T, which is known as a passive material, a lag time of 583 seconds was found. This indicates that polymer B is comparable to PVC-T, and more passive than polymer A. Polymer A exhibited minor activation of platelets. Polymer B did not induce platelet activation at all. The polymers exhibited, even as fibers with a diameter of ca. 0.3 mm, good radiopacity with routine imaging X-ray techniques in the clinic.(ABSTRACT TRUNCATED AT 250 WORDS)
制备了两种含有共价键合碘的新型聚合物材料（聚合物A和聚合物B）。对这些聚合物作为不透射线植入生物材料的潜在用途进行了评估，即使用常规X射线吸收成像技术以非侵入性方式可见的材料。聚合物A是甲基丙烯酸甲酯（MMA）和1的共聚物（分别为80和20摩尔%）。聚合物B由MMA、1和甲基丙烯酸2-羟乙酯（HEMA）制备（摩尔比分别为65:20:15）。化合物1由4-碘苯酚和甲基丙烯酰氯合成。通过凝胶渗透色谱法（GPC）、差示扫描量热法（DSC）、核磁共振（NMR）以及测量前进接触角和后退接触角对所得聚合物进行了表征。通过体外凝血酶生成测试程序测定聚合物的血栓形成性。聚合物A的游离凝血酶最大浓度为76±1 nM，聚合物B为64±3 nM。聚合物A的滞后时间（即凝血酶生成的起始时间）为392秒，聚合物B为553秒。对于已知为惰性材料的PVC-T，发现滞后时间为583秒。这表明聚合物B与PVC-T相当，且比聚合物A更具惰性。聚合物A对血小板有轻微激活作用。聚合物B根本不诱导血小板激活。即使作为直径约0.3 mm的纤维，这些聚合物在临床常规成像X射线技术下也表现出良好的不透射线性能。（摘要截断于250字）
