Geschwind Michael D, Shu Huidy, Haman Aissa, Sejvar James J, Miller Bruce L
University of California San Francisco Memory & Aging Center, Department of Neurology, San Francisco, CA 94143-1207, USA.
Ann Neurol. 2008 Jul;64(1):97-108. doi: 10.1002/ana.21430.
In contrast with more common dementing conditions that typically develop over years, rapidly progressive dementias can develop subacutely over months, weeks, or even days and be quickly fatal. Because many rapidly progressive dementias are treatable, it is paramount to evaluate and diagnose these patients quickly. This review summarizes recent advances in the understanding of the major categories of RPD and outlines efficient approaches to the diagnosis of the various neurodegenerative, toxic-metabolic, infectious, autoimmune, neoplastic, and other conditions that may progress rapidly.
与通常在数年时间里逐渐发展的更常见的痴呆症不同,快速进展性痴呆可在数月、数周甚至数天内亚急性起病,并迅速致命。由于许多快速进展性痴呆是可治疗的,因此快速评估和诊断这些患者至关重要。本综述总结了对快速进展性痴呆主要类型认识的最新进展,并概述了诊断各种可能快速进展的神经退行性、毒性代谢性、感染性、自身免疫性、肿瘤性及其他疾病的有效方法。