Gut. 1974 May;15(5):371-6. doi: 10.1136/gut.15.5.371.
Immunoglobulin-containing plasma cell densities in the jejunal mucosa and serum and jejunal fluid immunoglobulins have been measured in patients with adult coeliac disease and dermatitis herpetiformis with and without jejunal mucosal abnormality. Studies were performed in patients before and after treatment of the jejunal lesion.Total immunofluorescent plasma cells were increased in untreated adult coeliac disease and dermatitis herpetiformis patients with jejunal lesions, but in general the normal predominance of IgA > IgM > IgG was found. There was no difference from controls in IgA-containing cells in the two conditions before or after treatment. The numbers of IgM-containing cells were significantly increased both before and after treatment in groups of patients with adult coeliac disease and dermatitis herpetiformis who had jejunal lesions. IgG-containing cells were significantly raised in only the before-treatment groups. Patients with dermatitis herpetiformis without jejunal lesions, even whilst on gluten-containing diets, had normal numbers of immunoglobulin-containing cells. IgA and IgM jejunal fluid immunoglobulins were significantly raised in dermatitis herpetiformis and adult coeliac disease.It is concluded that patients with dermatitis herpetiformis with jejunal morphological abnormality have a comparable immunological disturbance of the jejunal mucosa to that found in adult coeliac disease.
在成人乳糜泻和疱疹样皮炎患者中,测量了有和无空肠黏膜异常的患者空肠黏膜和血清及空肠液中免疫球蛋白含浆细胞密度。在空肠病变治疗前后对患者进行了研究。未经治疗的成人乳糜泻和疱疹样皮炎伴有空肠病变的患者中,总免疫荧光浆细胞增加,但通常发现 IgA > IgM > IgG 占优势。在治疗前后,两种情况下 IgA 含细胞与对照组无差异。在有空肠病变的成人乳糜泻和疱疹样皮炎患者的治疗前后,IgM 含细胞数量均显著增加。仅在治疗前组中 IgG 含细胞升高。即使在食用含麸质饮食时,无空肠病变的疱疹样皮炎患者的免疫球蛋白含细胞数量也正常。疱疹样皮炎和成人乳糜泻患者的 IgA 和 IgM 空肠液免疫球蛋白均显著升高。结论:伴有空肠形态异常的疱疹样皮炎患者的空肠黏膜免疫紊乱与成人乳糜泻相似。