• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Challenges and pitfalls of combining targeted agents in phase I studies.

作者信息

Cannistra Stephen A

出版信息

J Clin Oncol. 2008 Aug 1;26(22):3665-7. doi: 10.1200/JCO.2008.17.2676.

DOI:10.1200/JCO.2008.17.2676
PMID:18669449
Abstract
摘要

相似文献

1
Challenges and pitfalls of combining targeted agents in phase I studies.I期研究中联合使用靶向药物的挑战与陷阱。
J Clin Oncol. 2008 Aug 1;26(22):3665-7. doi: 10.1200/JCO.2008.17.2676.
2
Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity.索拉非尼和贝伐单抗联合靶向治疗会导致毒性增强和抗肿瘤活性提高。
J Clin Oncol. 2008 Aug 1;26(22):3709-14. doi: 10.1200/JCO.2007.10.8332.
3
Paclitaxel in combination with sorafenib and bevacizumab in patients with locally advanced or metastatic solid tumors.紫杉醇联合索拉非尼和贝伐单抗治疗局部晚期或转移性实体瘤患者。
Int J Clin Pharmacol Ther. 2012 Jan;50(1):72-3. doi: 10.5414/cpp50072.
4
[Oncology 2008].
Dtsch Med Wochenschr. 2008 Jun;133(25-26):1395-9. doi: 10.1055/s-2008-1081075. Epub 2008 Jun 3.
5
[Adverse effects of new oncologic therapies].[新型肿瘤治疗的不良反应]
Praxis (Bern 1994). 2011 Jul 27;100(15):885-91; quiz 890. doi: 10.1024/1661-8157/a000609.
6
It takes two to tango: combinations of conventional cytotoxics with compounds targeting the vascular endothelial growth factor-vascular endothelial growth factor receptor pathway in patients with solid malignancies.双人探戈:在实体恶性肿瘤患者中,将传统细胞毒素药物与靶向血管内皮生长因子-血管内皮生长因子受体通路的化合物联合使用。
Cancer Sci. 2010 Jan;101(1):7-15. doi: 10.1111/j.1349-7006.2009.01369.x. Epub 2009 Sep 18.
7
[Targeted therapies and their indications in solid neoplasias].[实体瘤的靶向治疗及其适应症]
Rev Med Interne. 2009 May;30(5):416-24. doi: 10.1016/j.revmed.2008.12.022. Epub 2009 Mar 18.
8
Design of clinical trials of radiation combined with antiangiogenic therapy.放射治疗联合抗血管生成疗法的临床试验设计
Oncologist. 2007 Apr;12(4):465-77. doi: 10.1634/theoncologist.12-4-465.
9
[Interdisciplinary recommendations for the treatment of metastatic renal cell carcinoma].[转移性肾细胞癌治疗的跨学科建议]
Aktuelle Urol. 2009 Jan;40(1):27-30. doi: 10.1055/s-0028-1098786. Epub 2009 Jan 28.
10
Targeting angiogenesis in bladder cancer.靶向膀胱癌中的血管生成
Curr Oncol Rep. 2009 May;11(3):244-9. doi: 10.1007/s11912-009-0034-2.

引用本文的文献

1
A review of dose escalation for FDA-approved products treating solid tumors and hematological malignancies in first-in-human trials.在首次人体试验中,评估 FDA 批准的用于治疗实体瘤和血液系统恶性肿瘤的产品的剂量递增。
Clin Transl Oncol. 2024 Sep;26(9):2116-2125. doi: 10.1007/s12094-024-03451-2. Epub 2024 Apr 1.
2
Factors Affecting Combination Trial Success (FACTS): Investigator Survey Results on Early-Phase Combination Trials.影响联合试验成功的因素(FACTS):关于早期联合试验的研究者调查结果
Front Med (Lausanne). 2019 Jun 4;6:122. doi: 10.3389/fmed.2019.00122. eCollection 2019.
3
Dose-finding designs for trials of molecularly targeted agents and immunotherapies.
分子靶向药物和免疫疗法试验的剂量探索设计。
J Biopharm Stat. 2017;27(3):477-494. doi: 10.1080/10543406.2017.1289952. Epub 2017 Feb 6.
4
Dietary supplementation with Bifidobacterium longum subsp. infantis (B. infantis) in healthy breastfed infants: study protocol for a randomised controlled trial.健康母乳喂养婴儿中补充婴儿双歧杆菌亚种(婴儿双歧杆菌)的膳食研究:一项随机对照试验的研究方案。
Trials. 2016 Jul 22;17(1):340. doi: 10.1186/s13063-016-1467-1.
5
The changing landscape of phase I trials in oncology.肿瘤学中 I 期临床试验的变化格局。
Nat Rev Clin Oncol. 2016 Feb;13(2):106-17. doi: 10.1038/nrclinonc.2015.194. Epub 2015 Nov 10.
6
Clinical trials: Early phase clinical trials-are dose expansion cohorts needed?临床试验:早期临床试验——是否需要剂量扩展队列?
Nat Rev Clin Oncol. 2015 Nov;12(11):626-8. doi: 10.1038/nrclinonc.2015.174. Epub 2015 Oct 6.
7
Systems pharmacology approaches for optimization of antiangiogenic therapies: challenges and opportunities.用于优化抗血管生成疗法的系统药理学方法:挑战与机遇
Front Pharmacol. 2015 Feb 20;6:33. doi: 10.3389/fphar.2015.00033. eCollection 2015.
8
A Phase I/II adaptive design to determine the optimal treatment regimen from a set of combination immunotherapies in high-risk melanoma.一项I/II期适应性设计,旨在从一组高危黑色素瘤联合免疫疗法中确定最佳治疗方案。
Contemp Clin Trials. 2015 Mar;41:172-9. doi: 10.1016/j.cct.2015.01.016. Epub 2015 Jan 29.
9
Pharmacokinetic/Pharmacodynamic modeling of abexinostat-induced thrombocytopenia across different patient populations: application for the determination of the maximum tolerated doses in both lymphoma and solid tumour patients.阿贝西诺司他诱导不同患者群体血小板减少的药代动力学/药效学建模:用于确定淋巴瘤和实体瘤患者的最大耐受剂量
Invest New Drugs. 2014 Oct;32(5):985-94. doi: 10.1007/s10637-014-0118-1. Epub 2014 May 31.
10
Modeling NSCLC progression: recent advances and opportunities available.非小细胞肺癌进展的建模:最新进展与机遇。
AAPS J. 2013 Apr;15(2):542-50. doi: 10.1208/s12248-013-9461-y. Epub 2013 Feb 13.