Santoro L, Ragno M, Nucciotti R, Barbieri F, Caruso G
Department of Clinical Neurophysiology and Neurological Clinic, 2nd School of Medicine, University of Naples, Italy.
Acta Neurol (Napoli). 1991 Feb;13(1):13-8.
In a 54-year-old male a severe sensory neuropathy was observed during treatment for pulmonary tuberculosis with isoniazid (400 mg/day) and pyridoxine (600 mg/day). Eight months after withdrawal from isoniazid the sensory symptomatology was still progressing, although muscle strength was never reduced. A sural nerve biopsy revealed marked loss of large myelinated fibres. Only when pyridoxine treatment was interrupted did a slow improvement begin. A clinical and electrophysiologic follow-up showed a very slow and still incomplete recovery after four years. The possibility of an unusual individual susceptibility to toxic effects of pyridoxine is considered.
在一名54岁男性患者中，在使用异烟肼（400毫克/天）和吡哆醇（600毫克/天）治疗肺结核期间观察到严重的感觉神经病变。停用异烟肼8个月后，感觉症状仍在进展，尽管肌肉力量从未减弱。腓肠神经活检显示有髓大纤维明显丢失。只有当吡哆醇治疗中断后，才开始缓慢改善。临床和电生理随访显示，四年后恢复非常缓慢且仍不完全。考虑到个体对吡哆醇毒性作用存在异常易感性的可能性。
