Hooper Davyd R, Tarnopolsky Mark A, Baker Steven K
Department of Medicine, Neuromuscular Disease Clinic, Rm. 2H22, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5.
Muscle Nerve. 2008 Oct;38(4):1318-25. doi: 10.1002/mus.21051.
We report 2 cases of Lewis-Sumner syndrome (LSS) diagnosed in patients suffering from rheumatoid arthritis undergoing treatment with the antitumor necrosis factor alpha (TNF-alpha) monoclonal antibody infliximab. While experiencing clinical improvement in their arthritic symptoms, both patients experienced sensory deficits and weakness in multiple nerve distributions. They had electrodiagnostic evidence of motor conduction block and subsequent improvement with intravenous immunoglobulin (IVIg). We describe the details of the cases and review the literature on immune-mediated neuropathies associated with anti-TNF-alpha therapy.
我们报告了2例Lewis-Sumner综合征（LSS），这2例患者均为类风湿关节炎患者，正在接受抗肿瘤坏死因子α（TNF-α）单克隆抗体英夫利昔单抗治疗。尽管这2例患者的关节炎症状在临床上有所改善，但均出现了多神经分布区的感觉缺失和无力。他们有运动传导阻滞的电诊断证据，且随后静脉注射免疫球蛋白（IVIg）后症状有所改善。我们描述了这些病例的详细情况，并回顾了与抗TNF-α治疗相关的免疫介导性神经病的文献。
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