慢性炎性脱髓鞘性多发性神经根神经病中静脉注射免疫球蛋白反应性的临床及电生理相关性

Clinical and electrophysiologic correlates of IVIg responsiveness in CIDP.

作者信息

Iijima M, Yamamoto M, Hirayama M, Tanaka F, Katsuno M, Mori K, Koike H, Hattori N, Arimura K, Nakagawa M, Yoshikawa H, Hayasaka K, Onodera O, Baba M, Yasuda H, Saito T, Nakazato M, Nakashima K, Kira J, Kaji R, Oka N, Sobue G

机构信息

Department of Neurology, Nagoya University Graduate School of Medicine, Tsurumai, Nagoya, Japan.

出版信息

Neurology. 2005 Apr 26;64(8):1471-5. doi: 10.1212/01.WNL.0000158680.89323.F8.

DOI:10.1212/01.WNL.0000158680.89323.F8

PMID:15851750

Abstract

To identify clinical and electrophysiologic features related to IV immunoglobulin (IVIg) responsiveness in chronic inflammatory demyelinating polyneuropathy (CIDP), the authors conducted a multicenter study on 312 patients with CIDP (199 responders and 113 nonresponders). Muscle atrophy and decreased compound muscle action potential were pronounced in nonresponders of IVIg. Male gender, longer disease duration, and slow progression of symptoms were also associated with IVIg unresponsiveness. Features suggesting axonal dysfunction in peripheral nerves indicated IVIg unresponsiveness in CIDP.

摘要

为了确定与慢性炎症性脱髓鞘性多发性神经病（CIDP）中静脉注射免疫球蛋白（IVIg）反应性相关的临床和电生理特征，作者对312例CIDP患者（199例反应者和113例无反应者）进行了一项多中心研究。IVIg无反应者的肌肉萎缩和复合肌肉动作电位降低更为明显。男性、病程较长以及症状进展缓慢也与IVIg无反应性相关。提示周围神经轴索功能障碍的特征表明CIDP患者对IVIg无反应。