Kimura Makoto
Gene Engineering Division, RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki, Japan.
FEBS Lett. 2008 Aug 20;582(19):2833-7. doi: 10.1016/j.febslet.2008.07.033. Epub 2008 Jul 29.
Jun-dimerization protein 2 (JDP2) is a member of the activating protein-1 (AP-1) family of transcription factors. JDP2 dimerizes with other AP-1 proteins such as activating transcription factor-2 (ATF2) and Jun to repress transcription from promoters that contain a cyclic AMP-responsive element (CRE). Interferon regulatory factor-2-binding protein-1 (IRF2-BP1), which is reported to be a transcriptional corepressor of IRF2, was isolated as a JDP2-binding protein using an epitope-tagging method. As anticipated from the presence of a RING-finger domain, IRF2-BP1 enhanced the polyubiquitination of JDP2. Moreover, IRF2-BP1 repressed ATF2-mediated transcriptional activation from a CRE-containing promoter.
Jun二聚化蛋白2（JDP2）是转录因子激活蛋白-1（AP-1）家族的成员。JDP2与其他AP-1蛋白如激活转录因子-2（ATF2）和Jun二聚化，以抑制含有环磷酸腺苷反应元件（CRE）的启动子的转录。据报道，干扰素调节因子2结合蛋白1（IRF2-BP1）是IRF2的转录共抑制因子，采用表位标记法将其分离为JDP2结合蛋白。从存在的环指结构域可以预期，IRF2-BP1增强了JDP2的多聚泛素化。此外，IRF2-BP1抑制了含CRE启动子的ATF2介导的转录激活。
