Baumwart Ryan D, Meurs Kathryn M
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Am J Vet Res. 2008 Aug;69(8):1029-33. doi: 10.2460/ajvr.69.8.1029.
To use an index of myocardial performance (IMP) to assess right ventricular function in Boxers with arrhythmogenic right ventricular cardiomyopathy (ARVC).
22 Boxers (12 Boxers with ARVC diagnosed by the detection of > or = 1,000 ventricular premature complexes (VPCs)/24 h and 10 Boxers with < or = 5 VPCs/24 h (control dogs). Procedures-Pulsed-wave Doppler recordings of tricuspid inflow and pulmonic outflow were acquired. Preejection period (PEP), ejection time (ET), PEP/ET, and IMP were determined for the right ventricle by use of data from separate cardiac cycles.
A significant difference was not identified between groups for right ventricular PEP, right ventricular ET, right ventricular PEP/ET, or right ventricular IMP. Right ventricular IMP was not significantly correlated with VPC number (r = 0.21) or VPC grade (r = -0.3) in Boxers with ARVC.
Boxers with ARVC did not have significant differences in right ventricular IMP, compared with results for control Boxers. This would suggest that right ventricular dysfunction does not develop in Boxers with ARVC or that a more severe phenotype of the disease may be necessary for detection of dysfunction. Additional studies that use more sensitive techniques to evaluate myocardial function may be warranted.
使用心肌性能指数（IMP）评估患致心律失常性右室心肌病（ARVC）的拳师犬的右心室功能。
22只拳师犬（12只通过检测到≥1000次室性早搏（VPC）/24小时确诊为ARVC的拳师犬和10只VPC≤5次/24小时的拳师犬（对照犬））。方法——获取三尖瓣流入和肺动脉流出的脉冲波多普勒记录。利用来自不同心动周期的数据确定右心室的射血前期（PEP）、射血时间（ET）、PEP/ET和IMP。
两组在右心室PEP、右心室ET、右心室PEP/ET或右心室IMP方面未发现显著差异。在患有ARVC的拳师犬中，右心室IMP与VPC数量（r = 0.21）或VPC分级（r = -0.3）无显著相关性。
与对照拳师犬的结果相比，患有ARVC的拳师犬在右心室IMP方面无显著差异。这表明患有ARVC的拳师犬不会出现右心室功能障碍，或者可能需要更严重的疾病表型才能检测到功能障碍。可能有必要进行更多使用更敏感技术评估心肌功能的研究。
