Terzieva Velislava
Department of Immunology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Viral Immunol. 2008 Sep;21(3):285-91. doi: 10.1089/vim.2008.0006.
Recently, it has been emphasized that chronic generalized immune activation is a leading event in the pathogenesis of HIV-1 infection. Supporting evidence comes from observations that in cases of lack of activation, infected subjects maintain a high number of T cells and do not develop AIDS-related events. Despite intensive studies, the exact mechanisms of T-cell activation are still not well understood and options for their control are limited. Very promising in this direction is a recently described T-cell subpopulation--regulatory T cells. Their functional activity and vitality are strongly dependent on the presence of IL-2. Better understanding of the mechanisms of T-cell activation, as well as the contribution of regulatory T cells to its control will increase therapeutic options for HIV-1-infected subjects. The application of immune-based therapy together with highly active antiretroviral therapy will lend a helping hand to the natural regulatory mechanisms in the control of infection.
最近，有人强调慢性全身性免疫激活是HIV-1感染发病机制中的主要事件。支持这一观点的证据来自以下观察结果：在缺乏激活的情况下，受感染个体维持大量T细胞，且不会发生与艾滋病相关的事件。尽管进行了深入研究，但T细胞激活的确切机制仍未完全明确，控制这些机制的选择也很有限。在这个方向上非常有前景的是最近描述的一种T细胞亚群——调节性T细胞。它们的功能活性和活力强烈依赖于白细胞介素-2的存在。更好地理解T细胞激活机制以及调节性T细胞在控制该过程中的作用，将增加针对HIV-1感染个体的治疗选择。基于免疫的疗法与高效抗逆转录病毒疗法联合应用，将有助于自然调节机制控制感染。
