妊娠剧吐患者血清中腺苷脱氨酶及妊娠相关激素水平

Serum levels of adenosine deaminase and pregnancy-related hormones in hyperemesis gravidarum.

作者信息

Taşkin Salih, Taşkin Elif Aylin, Seval Mehmet Murat, Atabekoğlu Cem Somer, Berker Bulent, Söylemez Feride

机构信息

Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.

出版信息

J Perinat Med. 2009;37(1):32-5. doi: 10.1515/JPM.2009.013.

DOI:10.1515/JPM.2009.013

PMID:18673094

Abstract

OBJECTIVES

We investigated the correlation between pregnancy-related hormones and serum adenosine deaminase (indicator of cellular immunity) level in women with hyperemesis gravidarum.

MATERIALS AND METHODS

Twenty patients with hyperemesis gravidarum and 20 normal pregnancies were included in this prospective, case-control study. Serum adenosine deaminase levels, hematological parameters (white blood cells, neutrophil, monocyte and lymphocyte counts) and hormone levels (prolactin, progesterone, thyroid stimulating hormone, human chorionic gonadotropin beta subunit, estradiol (E2)) were measured in all women. Interrelations of blood cell counts and hormone levels with serum adenosine deaminase levels were also investigated.

RESULTS

Serum adenosine deaminase, human chorionic gonadotropin beta subunit, thyroid stimulating hormone, E2, progesterone and prolactin levels, and lymphocyte and monocyte counts in women with hyperemesis gravidarum were significantly higher than in controls but white blood cells, neutrophil, T3 and T4 levels were not different. Serum adenosine deaminase level correlated with E2, progesterone, lymphocyte, and monocyte levels for all patients.

CONCLUSION

Elevated serum adenosine deaminase in patients with hyperemesis gravidarum may relate to high levels of E2 and progesterone.

摘要

目的

我们研究了妊娠剧吐女性体内妊娠相关激素与血清腺苷脱氨酶（细胞免疫指标）水平之间的相关性。

材料与方法

这项前瞻性病例对照研究纳入了20例妊娠剧吐患者和20例正常妊娠女性。检测了所有女性的血清腺苷脱氨酶水平、血液学参数（白细胞、中性粒细胞、单核细胞和淋巴细胞计数）以及激素水平（催乳素、孕酮、促甲状腺激素、人绒毛膜促性腺激素β亚基、雌二醇（E2））。还研究了血细胞计数和激素水平与血清腺苷脱氨酶水平之间的相互关系。