妊娠剧吐患者的白细胞介素-6水平
Interleukin-6 levels in hyperemesis gravidarum.
作者信息
Kuscu Naci K, Yildirim Yasemin, Koyuncu Faik, Var Ahmet, Uyanik Bekir S
机构信息
Department of Obstetrics and Gynecology, School of Medicine, Celal Bayar University, 45020 Manisa, Turkey.
出版信息
Arch Gynecol Obstet. 2003 Nov;269(1):13-5. doi: 10.1007/s00404-002-0412-6. Epub 2003 Jan 24.
INTRODUCTION
Hyperemesis gravidarum (HG) is associated with higher levels of serum beta-hCG levels and hyperthyroidism. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is reported to enhance secretion of beta-hCG from trophoblastic cell line.
METHODS
We measured serum levels of IL-6, thyroid hormones and beta-hCG of hyperemetic patients and gestational age-matched controls to search for a difference between the two groups.
RESULTS
There was a significant difference in beta-hCG ( p=0.028), though IL-6 levels were higher in the hyperemetic group, it did not reach a significant level. Interleukin-6 positively correlated with beta-hCG ( r=0.38 and p=0.13).
引言
妊娠剧吐（HG）与血清β-人绒毛膜促性腺激素（β-hCG）水平升高及甲状腺功能亢进有关。白细胞介素-6（IL-6）是一种促炎细胞因子，据报道可增强滋养层细胞系中β-hCG的分泌。
方法
我们测量了妊娠剧吐患者和孕周匹配的对照组的血清IL-6、甲状腺激素和β-hCG水平，以寻找两组之间的差异。
结果
β-hCG存在显著差异（p = 0.028），尽管妊娠剧吐组的IL-6水平较高，但未达到显著水平。白细胞介素-6与β-hCG呈正相关（r = 0.38，p = 0.13）。
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