Kumar P, Mishra B
Department of Pharmaceutics Institute of Technology Banaras Hindu University, Varanasi-221005, India.
Curr Drug Deliv. 2008 Jul;5(3):186-98. doi: 10.2174/156720108784911712.
In the last two decades colon targeted drug delivery has gained increased importance not just for the deliver drugs for the treatment of various colonic diseases but also for its potential for delivery of proteins and therapeutic peptides. In the past various traditional approaches used for colon targeted delivery like prodrugs, pH, time dependent, and microflora activated systems, have achieved limited success. For successful colon targeted drug delivery, the drug needs to be protected from absorption and/or the environment of the upper gastrointestinal tract and then be abruptly released into the colon. Hence continuous efforts have been made on designing colon targeted drug delivery systems with improved site specificity and versatile drug release kinetics to fulfill different therapeutic needs. In last couple of years few new systems have been developed for colon targeted drug delivery such as pressure dependent systems, CODES technology, microsponges, pectin and galactomannan coating, microbially triggered osmotic systems, lectins and neoglyconjugated etc. which are reported to have better in-vivo site specificity and design rationale than the earlier approaches. This review article gives an overview of various approaches for colonic targeted drug delivery with emphasis on newer systems, their merits and demerits, in vitro/ in-vivo evaluation and market status of such delivery systems.
在过去二十年中，结肠靶向给药不仅在递送用于治疗各种结肠疾病的药物方面变得越来越重要，而且在递送蛋白质和治疗性肽方面也具有潜力。过去，用于结肠靶向递送的各种传统方法，如前体药物、pH值依赖、时间依赖和微生物激活系统，取得的成功有限。为了实现成功的结肠靶向给药，药物需要避免在上消化道被吸收和/或免受其环境影响，然后突然释放到结肠中。因此，人们一直在不断努力设计具有更高位点特异性和通用药物释放动力学的结肠靶向给药系统，以满足不同的治疗需求。在过去几年中，已经开发了一些用于结肠靶向给药的新系统，如压力依赖系统、CODES技术、微海绵、果胶和半乳甘露聚糖包衣、微生物触发渗透系统、凝集素和新糖缀合物等，据报道这些系统比早期方法具有更好的体内位点特异性和设计原理。这篇综述文章概述了结肠靶向给药的各种方法，重点介绍了较新的系统、它们的优缺点、体外/体内评估以及此类给药系统的市场状况。
